Late-onset neurodegenerative diseases-the role of protein insolubility

Role of Protein Aggregation in Neurodegenerative Diseases

Proteins and peptides are essential complex macromolecules of organisms and participate in actually every process within cells. Three dimensional structures of proteins play a critical role for biological functions. Therefore, they must be properly folded for performing these functions. Three dimensional structures are determined by composition of amino acid se‐ quence. In addition to hydrophob...

Role of autophagy in prion protein-induced neurodegenerative diseases.

Prion diseases, characterized by spongiform degeneration and the accumulation of misfolded and aggregated PrP(Sc) in the central nervous system, are one of fatal neurodegenerative and infectious disorders of humans and animals. In earlier studies, autophagy vacuoles in neurons were frequently observed in neurodegenerative diseases such as Alzheimer's, Parkinson's, and Huntington's diseases as w...

The Role of Epigenetics in Neurodegenerative Diseases

the analysis of the role of the speech acts theory in translating and dubbing hollywood films

از محوری ترین اثراتی که یک فیلم سینمایی ایجاد می کند دیالوگ هایی است که هنرپیش گان فیلم میگویند. به زعم یک فیلم ساز, یک شیوه متأثر نمودن مخاطب از اثر منظوره نیروی گفتارهای گوینده, مثل نیروی عاطفی, ترس آور, غم انگیز, هیجان انگیز و غیره, است. این مطالعه به بررسی این مسأله مبادرت کرده است که آیا نیروی فراگفتاری هنرپیش گان به مثابه ی اعمال گفتاری در پنج فیلم هالیوودی در نسخه های دوبله شده باز تولید...

Emerging role of mitochondria dysfunction in the onset of neurodegenerative diseases.

Mitochondria play a pivotal role in a number of biochemical processes in the neuron including energy metabolism and ATP production, intracellular Ca2+ homeostasis and cell signalling which are all implicated in the regulation of neuronal excitability. For this reason, it is not surprising that alterations in mitochondrial function have emerged as a hallmark of aging and various age-related neur...